Heme and Iron

H & I Main Menu
Heme metabolism
Heme synthesis
Heme degradation
Iron topics
Heme and Iron -- Main Menu

Heme metabolism is an important metabolic process because many important proteins contain heme as a prosthetic group. When these hemoproteins turn over, the heme is not salvaged, but is degraded. New heme is synthesized for their replacements.

Heme is a member of a family of compounds called porphyrins.
(text, sound, graphics, animation with sound)

Heme synthesis occurs partly in the mitochondria and partly in the cytoplasm. The process begins in the mitochondria because one of the precursors is found only there. Since this reaction is regulated in part by the concentration of heme, the final step (which produces the heme) is also mitochondrial. Most of the intermediate steps are cytoplasmic.
(text,sound, graphics)

Porphyrias are defects in porphyrin metabolism.
(text,sound, graphics)

Heme degradation is an important metabolic process.
(text,sound, graphics)

Iron topics: metabolism, absorption, regulation of iron uptake, transport, storage.
(text, graphics)

Test yourself with some multiple choice exam questions.

Home > Heme and Iron >Main Menu (updated 2003/11/02)