d-aminolevulinic acid synthase:
- Requires pyridoxal phosphate for activity.
- Synthesis can be induced by phenobarbital and some steroids.
- Is inhibited by heme.
Is inhibited by lead.
- A, B and C
A and C
B and D
All of the above
- Pyridoxal (vitamin B6) phosphate antagonists, such as the anti-tuberculosis drug, isoniazide, can inhibit this enzyme.
- Phenobarbital is contraindicated for patients with porphyria for this reason.
- This is a major physiological control.
- ALA dehydratase and ferrochelatase are notably lead-sensitive.
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